Affinities of SM-7338 for penicillin-binding proteins and its release from these proteins in Staphylococcus aureus.

نویسندگان

  • Y Sumita
  • M Fukasawa
  • T Okuda
چکیده

SM-7338, a carbapenem antibiotic, had high affinities for penicillin-binding proteins (PBPs) 1, 2, and 4 of Staphylococcus aureus but not for PBP 3 when a competition assay with [14C]benzylpenicillin was used. However, binding of [14C]SM-7338 was saturated for PBP 3 at a concentration of 1 microgram/ml. These results were due to the rapid release of SM-7338 from PBP 3-SM-7338 complexes with a half-life of 2 min.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 34 3  شماره 

صفحات  -

تاریخ انتشار 1990